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I don't think Thatcher destroyed, or finished off, British manufacturing. I think she refused to back severely failing nationalised industries but was more than willing to support proper business.
She refused to back down from confrontation with the unions, the miners being a prime example. Should she have closed mining or forced the miner's union to behave more responsibly? That's a tough one. One thing is for sure, there wasn't a major strike of that ilk again.
Did she go too far with industrial/union reform? Probably.
With "Big Bang" and other actions she made it clear where her priorities lay in the promotion of the City and related Financial Services.
Innovations in manufacturing received less encouragement.
She did succeed in restoring parliamentary democracy with her defiance of the union barons but, as you suggest, she allowed herself to be carried away by her initial success.
As with all PM's there were positives and negatives.