Absolutely, me/wife made the mistake of thinking there wasn't a lot of difference. Wife is 'short' and not a quick swing speed.
She first bought a cheap set of mens regular graphite hippo irons. The typical flight was low low low.
I bought an almost complete setup of cobra fly z(xl ? I think, no driver) ladies graphite irons off a pro/ebay for less than £200 new iirc, and the difference between them and the hippos, were massive, wish we had bought a proper set first off. The flight is so much higher, she is far more consistent with them etc. Feel wise they feel really whippy and lighter (she and I noticed that, and it took her a while to adjust to the feel, but results were instant almost). Would really recommend the irons btw.
Woods/hybrids that came with the iron set, she basically doesn't hit. She doesn't hit anything above a 9 wood(an old adams), as she doesn't have the swing speed to launch them high enough & her strike is not good(shes a 26ish hcapper btw), something to bear in mind depending on how your wife swings and saving money
Driver she always had ladies cobra fly z driver, it is a high launch 12 degree driver, set to the max degrees which I think is 14(or is it 14 turned upto 16, can check if you need to know)