We went to see 2:22 a few weeks ago in the Criterion with Laura Whitmore in the female lead, and I did wonder about her - being the previous presenter of Love Island. But she was great, and the play was great also. I think Cheryl will be fine as the part ‘simply‘ calls for the female lead to act the part of a paranoid and sometimes manic young mum ?.
I see the rest of the cast has also changed (they will be the fifth cast I think as they change it quite regularly for each new season …Lily Allen was the lead before Whitmore) but that won’t make any difference due to the nature, setting and context of the play. I won’t say anything at all about the plot but I’m pretty sure that you (and @Oddsocks
) will enjoy it.