Coronavirus - how is it/has it affected you?

Ethan said:
The interim data showed that the low dose-high dose combination was more effective. The vaccine is constructed from the genetic sequence/blueprint for the Covid spike protein inserted into a harmless adenovirus, and some have theorised that when given in low dose it stimulates a lower immune response to the adenovirus, so the patient is able to response better to the subsequent booster. However, the data set for this combo was not huge, as it was a side question (with some serendipitous additional patents) to the main high dose-high dose question. So the MHRA is really mainly reviewing the high dose-high dose version, despite the fact that many now think the low-high combo would be preferable. It would make the scarce resource go a bit further, for a start.

Interestingly, the Russian vaccine makers also identified the same problem that Oxford may have partly intentionally, partly serendipitously also identified, and they approach the immunogenicity of the adenovirus by using different strains for the primary and the booster, thus swerving any immune response triggered by the primary.
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Thanks for that explanation. Completely answers my query.
Genuinely, Lord knows what we'd be speculating on if you weren't here to answer these techy thoughts of ours.?
 
Well COVID has now reached our household.

An outbreak at my wife’s school right at the end of the term led to several teaching testing positive on Wed/thurs/friday, so we both went for a test on Friday. The results came back negative for both. Neither of us were showing symptoms so we thought we had escaped. A couple of other teachers who tested negative had started showing symptoms by Christmas Eve, so had a test again and came out positive. The wife and I were still showing no symptoms, but she is a very anxious person so went for another test on Christmas Day. Yesterday evening, the wife gets a call from one of her colleagues and is informed that one of the staff has passed away due to COVID, I believe she was in her 60’s but not considered vulnerable. In the early hours of this morning, the wife got her results back as positive but still showing no symptoms.
 
Really feeling the misery for a mate of mine.
He got pinged by T&T in mid December so had to isolate for 10 days.
2 days out of that and his Mrs wakes up with a raging temperature
She gets tested but doesn't hear anything so they chase.
It seems they've lost the swab somewhere:rolleyes:
So it's either back for another test or stay put untill Thursday....she's on the mend so it may not even have been Covid but its wrecked any chance of him playing golf..
 
SteveW86 said:
Well COVID has now reached our household.

An outbreak at my wife’s school right at the end of the term led to several teaching testing positive on Wed/thurs/friday, so we both went for a test on Friday. The results came back negative for both. Neither of us were showing symptoms so we thought we had escaped. A couple of other teachers who tested negative had started showing symptoms by Christmas Eve, so had a test again and came out positive. The wife and I were still showing no symptoms, but she is a very anxious person so went for another test on Christmas Day. Yesterday evening, the wife gets a call from one of her colleagues and is informed that one of the staff has passed away due to COVID, I believe she was in her 60’s but not considered vulnerable. In the early hours of this morning, the wife got her results back as positive but still showing no symptoms.
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Strange how we know the Covids out there, but don’t really feel it’s effects until it hits close to home, someone we love. Then it’s like a hammer blow. Gutted for your wife’s mate. The knock on effect at the school will be massive.

Taking lad for a covid test in 10 mins.
 
Would be nice if just occasionally the ‘Blair haters’ might acknowledge he may have a point; might even be correct and worth listening to.

Meanwhile I can breath a sigh of relief and give thanks that our PM has managed to secure a deal with the EU given the significant economic and social challenges the pandemic is going to present to the country in 2021 and the coming years. And so for that...well done PM. That agreement was desperately needed.
 
SwingsitlikeHogan said:
Would be nice if just occasionally the ‘Blair haters’ might acknowledge he may have a point; might even be correct and worth listening to.

Meanwhile I can breath a sigh of relief and give thanks that our PM has managed to secure a deal with the EU given the significant economic and social challenges the pandemic is going to present to the country in 2021 and the coming years. And so for that...well done PM. That agreement was desperately needed.
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Apparently the current gov have highlighted those 15 million that need a vaccine to remove need for lockdowns as with them vaccinated the NHS wouldn't reach full levels if it hit general population

Oxford vaccine approval Monday with roll out from the 4th they said 2 million a week

Lockdowns no longer needed by end of Feb

If they achieve that fair enough sceptical
 
pauljames87 said:
Apparently the current gov have highlighted those 15 million that need a vaccine to remove need for lockdowns as with them vaccinated the NHS wouldn't reach full levels if it hit general population

Oxford vaccine approval Monday with roll out from the 4th they said 2 million a week

Lockdowns no longer needed by end of Feb

If they achieve that fair enough sceptical
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What I do find odd ( unless Ave not seen it anywhere) is how many per day are being vaccinated. Throughout this Covid we have been wined and dined on a daily basis re facts and figures. There has been countless arguments and discussions re these figures. Most of which have been Grim. I read this morning that almost a million vaccinations have been done and that for me is brilliant. A daily update re numbers vaccinated could be a real “ shot in the arm” ? and positive news that folk are desperate for.
That said, these next 8 weeks are Imperative. The scales are finely balanced re the vaccinations and the new strain of Covid. The vaccinations will not be given any quicker. Whether the village idiots pay any attention to the lockdown rules to stop the spread is anyone’s guess.

#stay safe.
 
pauljames87 said:
Apparently the current gov have highlighted those 15 million that need a vaccine to remove need for lockdowns as with them vaccinated the NHS wouldn't reach full levels if it hit general population

Oxford vaccine approval Monday with roll out from the 4th they said 2 million a week

Lockdowns no longer needed by end of Feb

If they achieve that fair enough sceptical
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We were due to set up today ready for the Oxford jabs tomorrow, another delay and no further dates given. Keep putting this back, wonder what the issues are.
 
Old Skier said:
We were due to set up today ready for the Oxford jabs tomorrow, another delay and no further dates given. Keep putting this back, wonder what the issues are.
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Well, it isn't approved yet and it is impossible to predict with certainty what date it will be approved. If it doesn't get the nod in the next week or so, the UK vaccination plan stalls completely because there isn't much Pfizer floating around, and even some concern that there hasn't been enough set aside for second jabs for those who got their first jabs. The Johnson and Johnson vacc (broadly similar to the Oxford) is likely to get approved late Jan-early Feb, and they have the manufacturing scale to make quite a bit, so that will kick in relatively soon and could be vital.

I am also reading a lot of unhappiness on doctors.net that NHS prioritisation is up the left in some places, with young back-office admin and IT staff getting it before frontline middle aged doctors and nurses.
 
Ethan said:
Well, it isn't approved yet and it is impossible to predict with certainty what date it will be approved. If it doesn't get the nod in the next week or so, the UK vaccination plan stalls completely because there isn't much Pfizer floating around, and even some concern that there hasn't been enough set aside for second jabs for those who got their first jabs. The Johnson and Johnson vacc (broadly similar to the Oxford) is likely to get approved late Jan-early Feb, and they have the manufacturing scale to make quite a bit, so that will kick in relatively soon and could be vital.

I am also reading a lot of unhappiness on doctors.net that NHS prioritisation is up the left in some places, with young back-office admin and IT staff getting it before frontline middle aged doctors and nurses.
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Been cases in S Devon were people hadn’t turned up so those in charge have just grabbed staff, any staff to maximize the use of the vaccine.
 
Old Skier said:
Been cases in S Devon were people hadn’t turned up so those in charge have just grabbed staff, any staff to maximize the use of the vaccine.
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And they are right to do so. Better to give it to someone/anyone than waste it. I know a few people who got calls in the evening telling them if they can get to the vaccination site in the next 10 or 15 mins they can have a shot that otherwise will be going down the drain.
 
Ethan said:
And they are right to do so. Better to give it to someone/anyone than waste it. I know a few people who got calls in the evening telling them if they can get to the vaccination site in the next 10 or 15 mins they can have a shot that otherwise will be going down the drain.
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Will this be different with Oxford which needs a less strict cooling regime?
 
So the reports suggest that the new strains affect kids. Do they mean a higher propensity to be infected or experience a more severe/dangerous illness, or both.

Reports and claims we should shut schools seem to emphasise teenagers but does it behave the same with under 12s etc.
 
drdel said:
So the reports suggest that the new strains affect kids. Do they mean a higher propensity to be infected or experience a more severe/dangerous illness, or both.

Reports and claims we should shut schools seem to emphasise teenagers but does it behave the same with under 12s etc.
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I don't think there is any evidence that it is more severe in anybody at any age at the moment.
The only study that I read didn't really suggest that it had any differential in infectivity at different ages compared with the original Covid (that is to say it was increased in everyone but not more so in a particular group) but said it was possible.
 
SteveW86 said:
Well COVID has now reached our household.

An outbreak at my wife’s school right at the end of the term led to several teaching testing positive on Wed/thurs/friday, so we both went for a test on Friday. The results came back negative for both. Neither of us were showing symptoms so we thought we had escaped. A couple of other teachers who tested negative had started showing symptoms by Christmas Eve, so had a test again and came out positive. The wife and I were still showing no symptoms, but she is a very anxious person so went for another test on Christmas Day. Yesterday evening, the wife gets a call from one of her colleagues and is informed that one of the staff has passed away due to COVID, I believe she was in her 60’s but not considered vulnerable. In the early hours of this morning, the wife got her results back as positive but still showing no symptoms.
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My ex wife tested positive 3/4 weeks ago but never developed any symptoms her next test was clear.
She's 77 and in a care home suffering advanced dementia, her Covid vaccination is expected next week. Take care Steve (y)
 
williamalex1 said:
My ex wife tested positive 3/4 weeks ago but never developed any symptoms her next test was clear.
She's 77 and in a care home suffering advanced dementia, her Covid vaccination is expected next week. Take care Steve (y)
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How long between the tests was there. It’s a bit of a strange situation, as if she didn’t have the second test to ease her anxiety after her colleague passed away she would be allowed out tomorrow potentially passing it onto other people.
 
SteveW86 said:
How long between the tests was there. It’s a bit of a strange situation, as if she didn’t have the second test to ease her anxiety after her colleague passed away she would be allowed out tomorrow potentially passing it onto other people.
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According to my daughter it was 2 weeks between tests.
 
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