Coronavirus - how is it/has it affected you?

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That's the thing with endemic infections, they get around.
You have been reading Pagels twitter page again, said not to. I heard you cant beat going to 'alot' of shops once you have shown symptoms whilst being so careful. Think that might help to get it around.

Prof. Christina Pagel on Twitter: "Secondly masks: the first symptoms were so innocuous it was only obvious later what they were. I was 100% convinced we didn't have Covid cos we'd been so careful. The weekend before symptoms and 1st day of, we were in *a lot* of shops. 3/8" / Twitter

Its amazing what people post and think its okay to and from people who should know better.o_O
 
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It is not supposition to look at cases and death rates through last year until now. There is simply a different time dynamic between the UK and some other large European countries. I am not anti-AZ vaccine, I have frequently said that it is a good vaccine and has a role. But it is not a matter of opinion that it is less effective than the mRNAs. Sorry if that displeases you, but that is how it is. I also believe, as do others in industry, that AZ was not the right partner for Oxford, and a partner with a track record of vaccine development and scalable manufacturing capacity would have been better.

Pascal Soriot has established his own track record of saying stuff that was later shown to be incorrect, starting with the timelines and quantities expected for the AZ vaccine. Credence is earned. He admitted yesterday that there is no evidence at all of what he says and the response in social media within the UK medical community has been in line with mine. If you have a theory about how a markedly superior effect on antibodies by mRNAs over adenovirus vectors is overturned to become a superior effect on T-cells by the adenovirus vectors, which is essentially what he was waffling about, I would be happy to see it. The conventional understanding of the human immune response to vaccines can then be rewritten.

I don't blame Soriot for puffing up his product, just as they announce they intend to make some money from it, but he was not talking science he was doing PR. I thought you would have spotted that.

Edit: See this twitter thread from Christina Pagel on UK vs Europe comparisons: link
Just for the record; in 2014 Pfizer made an unsolicited bid for AZ which was rejected
 

Hobbit

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Daughter #2 has Covid, as does the g´daughter. They were at a family party on Saturday. 42 people!! Surely therés an indoor limit in the UK, or is there just recommendations?
Two more g’children, who were at the party, have it. Daughter-in-law thought one of them was ill but went anyway…. “Walks away shaking head…”
 
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Needles have a coloured plastic piece where they connect to the syringe. This denotes the width of the channel in the needle. This is important because some medicines that are injected are thick, and sometimes blood drawn can be damaged if the needle is too thin.

The normal blood sample needle is a green needle, which has a 21G thickness. There is another commonly used thinner needle, a blue needle, with a 23G thickness. This is sometimes used for blood sample in kids or in tricky veins. IM injection usually uses the blue needle, or even one size thinner. All of the needles are very sharp, which helps. The main unpleasantness is trying to push it through the skin. If it slips in like a hot knife through butter, much less pain. A good injector should usually be able to inject basically without any pain. A good decisive action is best, hesitation or fumbling is not good.

If you are unfortunate enough to be in an accident or other situation where you need fluid resuscitation with large volumes of (often rather gloopy) fluid administered fast, then a needle or cannula that looks more like a knitting needle will be used. Flow rates are related to the 4th power of the radius of a pipe or tube, so getting in a larger needle/cannula increases flow rate a huge amount especially something gloppy like blood or colloid.
While getting a cannula put in yesterday, for a CT heart scan, the nurse explained to the young student nurse how to insert and remove it, to prevent/reduce any bruising.
She said " when taking the cannula out ,immediately exert pressure on the exit wound and press hard for at least 20 seconds then check, especially if the patient is on any blood thinning meds ".
It worked very well , I never felt a thing going in or out and not a bruise in site, happy days.
I just hope the results are as good :eek:(y)
 

Ethan

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While getting a cannula put in yesterday, for a CT heart scan, the nurse explained to the young student nurse how to insert and remove it, to prevent/reduce any bruising.
She said " when taking the cannula out ,immediately exert pressure on the exit wound and press hard for at least 20 seconds then check, especially if the patient is on any blood thinning meds ".
It worked very well , I never felt a thing going in or out and not a bruise in site, happy days.
I just hope the results are as good :eek:(y)
She's not wrong. A piece of cotton and a bit of tape is no good.
 
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if the current rate of new infections keeps up everyone in the country will have had the virus in four years.
The German health minister (until yesterday, I think. They signed the new coalition contracts, big reshuffle coming) is expecting everyone to have had it this winter. He expressed it a bit more dramatic.

Geimpft, genesen, gestorben.
Translates to vaccinated, recovered or died. Didn’t mention be a group of not vaccinated and having avoided it all along.

It’s a pun on the rules of eventsor public transport in Germany, geimpft, genesen, getestet.

Anyway, it’s herd immunity reached. Luckily mostly by vaccination.
 

Foxholer

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Still bending the facts...
:ROFLMAO::ROFLMAO::ROFLMAO:
...the Government of the day stepped in due to competition interests....
Twaddle!
While there was certainly (understandable) 'interest' by/from the Government at the time - and no doubt plenty of discussion/chatter at 'clubs' - the rejection was 'purely' financial and by AZ. Plenty of articles still around to remind/correct your memory!
 
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Ethan

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Still bending the facts: the Government of the day stepped in due to competition interests. Enough of a tangent.
I think you started the tangent.

On the deal, surely AZ declined the revised Pfizer bid as not having increased enough. The UK Govt had not formally intervened and would have needed to use EU law to do so.
 
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I know. They should have accepted it. Soriot was CEO then, but, as I said here earlier, overplayed his hand and Pfizer got fed up and walked.
and very glad they failed as they would have likely stripped out growth form the UK market in the pharma area rather than the significant investment that has occured - new £1 billion cambridge campus opening right now for example. And it leaves one of the top UK companies as a UK company. But more importantly, AZ shares were undervalued in the bid and Soiret has delivered brilliant returns for the investors and fund managers that backed him. The shares have roughly doubled since the bid and that return is reflected in pension funds of UK people rather than losing one of the footsies best performers. Pfizer shares in mid 2020 - before the massive covid boost - were trading flat to when they made the bid in Q2 2014 - and put that into even more context - the FTSE 100 is about 10% higher in the last 7.5 years - the S&P 500 is up near 140%.

So not quite sure how he overplayed his hand!
 

Ethan

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and very glad they failed as they would have likely stripped out growth form the UK market in the pharma area rather than the significant investment that has occured - new £1 billion cambridge campus opening right now for example. And it leaves one of the top UK companies as a UK company. But more importantly, AZ shares were undervalued in the bid and Soiret has delivered brilliant returns for the investors and fund managers that backed him. The shares have roughly doubled since the bid and that return is reflected in pension funds of UK people rather than losing one of the footsies best performers. Pfizer shares in mid 2020 - before the massive covid boost - were trading flat to when they made the bid in Q2 2014 - and put that into even more context - the FTSE 100 is about 10% higher in the last 7.5 years - the S&P 500 is up near 140%.

So not quite sure how he overplayed his hand!
Because he had been charged by his Board to get a big deal and a deal with Pfizer was considered a very big one indeed. AZ shares were valued by Pfizer at 45% over the value right before Pfizer expressed an interest, and as the deal was essentially a tax inversion deal, it should have brought more Pfizer activity to the UK. AZ is a Swedish-UK company (in same order as the constituent names). The US remains their biggest market, so access there via Pfizer's monstrous marketing machine could have driven sales quite strongly and would have benefitted the bottom line in the UK.

Yahoo tells me that PFE share price in April 2014, when the AZ bid was made was in the area (depending on date) of $28. It is $50.89 now. I see you have fished around for the recent low point for your comparison. On the same day as that low PFE price, AZ share price was also at a recent low, £6.316, now £8.551. I am not sure you can make much of an argument out of that.

Soriot has made big pronouncements and predictions before, and on the Covid vaccine a few of them, mostly on timelines and supply, dramatically failed to materialise.

AZ is a great company in some areas, oncology, for example, but was not a major vaccine developer or maker. They have done well in recent years, much of that based on long-standing development projects. Some of the acquisitions and licensing deals done in recent years have yet to play out, because there is a long lead time, but they may be great.
 
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Because he had been charged by his Board to get a big deal and a deal with Pfizer was considered a very big one indeed. AZ shares were valued by Pfizer at 45% over the value right before Pfizer expressed an interest, and as the deal was essentially a tax inversion deal, it should have brought more Pfizer activity to the UK. AZ is a Swedish-UK company (in same order as the constituent names). The US remains their biggest market, so access there via Pfizer's monstrous marketing machine could have driven sales quite strongly and would have benefitted the bottom line in the UK.

Yahoo tells me that PFE share price in April 2014, when the AZ bid was made was in the area (depending on date) of $28. It is $50.89 now. I see you have fished around for the recent low point for your comparison. On the same day as that low PFE price, AZ share price was also at a recent low, £6.316, now £8.551. I am not sure you can make much of an argument out of that.

Soriot has made big pronouncements and predictions before, and on the Covid vaccine a few of them, mostly on timelines and supply, dramatically failed to materialise.

AZ is a great company in some areas, oncology, for example, but was not a major vaccine developer or maker. They have done well in recent years, much of that based on long-standing development projects. Some of the acquisitions and licensing deals done in recent years have yet to play out, because there is a long lead time, but they may be great.
i took mmid 2020 for Pfizer as they have obviously made tens of billions from covid - but even looking at the share price now - $50, compared to when they bid in 2014 of around $30, they will have still underperfromed Astra. And it was nice to see the bid rejected and another British (Anglo-Swiss. Yes. More British than Swiss if you count it has its global headquarters in the uk and Zenecca shareholders had 53.5% of the merged comapny and its primary listing is on the LSE and it is a PLC - a public company under UK law) company remain headquarterd, part of the local indices and a global success story. If you compare AZ share price before the bid interst then they would be 200%+ up. It just shows how undervalued they were and that they had a great deal in the pipeline, that they have delivered on that and that they remain British and that investors saw through the quick buck to be made and focused on the long-term value. And all of our pension savings have benefitted from that.
 
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Ethan

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i took mmid 2020 for Pfizer as they have obviously made tens of billions from covid - but even looking at the share price now - $50, compared to when they bid in 2014 of around $30, they will have still underperfromed Astra. And it was nice to see the bid rejected and another British (Anglo-Swiss. Yes. More British than Swiss if you count it has its global headquarters in the uk and Zenecca shareholders had 53.5% of the merged comapny and its primary listing is on the LSE and it is a PLC - a public company under UK law) company remain headquarterd, part of the local indices and a global success story. If you compare AZ share price before the bid interst then they would be 200%+ up. It just shows how undervalued they were and that they had a great deal in the pipeline, that they have delivered on that and that they remain British and that investors saw through the quick buck to be made and focused on the long-term value. And all of our pension savings have benefitted from that.
Cool. It is kinda cute the way you cling to the nationalistic issue. In reality, AZ are a multinational global company. So are GSK. Your pension pot should be benefitting from global companies. Mine does. Keep watching those share prices. Hope you noticed those which fell due to Brexit-related harm too.
 
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Cool. It is kinda cute the way you cling to the nationalistic issue. In reality, AZ are a multinational global company. So are GSK. Your pension pot should be benefitting from global companies. Mine does. Keep watching those share prices. Hope you noticed those which fell due to Brexit-related harm too.
it's kinda cute you seem to take the un-nationalistic approach on most issues - and you brought up brexit just now - that was nothing to do what i was talking about. But hey-ho, any chance for a dig and to link something spurious back to that event (one that i voted against FWIW) or government policies. And the fact is that having Astra as a UK company has benefitted our pensions AND has clearly been proven to be a smart move by not accepting Pfizer's bid for anyone holding the shares. Most UK pensions are much more biased to UK than global and more investors are likely to choose UK funds than global (much more so when you weight the capitalisation of the UK market in global terms - it is less than 5% and most people have way more than that as a % in uk invested assets), and mom and pop etc are much more likely to have some money in a UK listed company than a US listed alternative - so the more breadth of "local" options the better
 

AmandaJR

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Shopping at Lidl today and mask wearing at an all time low. I'd say 10% and most of those seem to have forgotten all about social distancing as they reached over people whilst chatting away to their shopping buddy. I just got madder and madder. It's like this pandemic hasn't happened and isn't happening - idiots.

The upside of a mask is I can mouth all sorts of obscenities in their direction and not get into a Lidl scrap!
 
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My friend is still hanging in there, just. Speaking to his daughter today it turns out no one medical thought to tell him his vaccines would be far less effective as he is on immunosupressants. Had he known chances are he would have been far more careful:cry:
 
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Shopping at Lidl today and mask wearing at an all time low. I'd say 10% and most of those seem to have forgotten all about social distancing as they reached over people whilst chatting away to their shopping buddy. I just got madder and madder. It's like this pandemic hasn't happened and isn't happening - idiots.

The upside of a mask is I can mouth all sorts of obscenities in their direction and not get into a Lidl scrap!
Same on the train home each day. The one I get is full of school kids (one of the highest spreaders at the moment and loads of kids at HID's school testing positive). I could get a bus home but again full of kids so not taking that risk. I keep my mask on during the train journey and now sitting in a carriage further away from the barriers where less people congregate
 
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:ROFLMAO::ROFLMAO::ROFLMAO:

Twaddle!
While there was certainly (understandable) 'interest' by/from the Government at the time - and no doubt plenty of discussion/chatter at 'clubs' - the rejection was 'purely' financial and by AZ. Plenty of articles still around to remind/correct your memory!
I fail to see why you need to be childishly rude when you make your prouncements, comments which are after all just opinions.
 
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